Burak Gulen

Georgia Institute of Technology, IBB 1203

PhD in Biochemistry, Georgia Institute of Technology, Atlanta,GA, USA, 2015 (Graduation: May 1st, 2015)
M.S. in Biochemistry, Georgia Institute of Technology, Atlanta,GA, USA, 2012
B.S. in Chemistry, Dokuz Eylul University, Izmir, Turkey, 2009

Research Interests: 

Burak's research interests are broadly ribosomal architecture and translation, drug targeting, molecular mimicry, and origins of life. His special focus is currently small ribosomal subunit and its architecture and dynamics. He is using biochemistry, chemistry, biophysical chemistry, analytical chemistry and microbiology approaches in his studies. Molecular cloning, protein expression and purification, RNA transcription and purification,  yeast three hybrid system, site-directed mutagenesis, chemical probing, SHAPE (Selective 2'OH acylation analyzed by primer extension), protein and nucleic acid engineering, circular dichroism spectroscopy, UV absorbance spectroscopy, fluorescence spectroscopy, UV/CD melting, EMSA (electrophoretic mobility shift assay), dynamic light scattering, gel electrophoresis, capillary electrophoresis, affinity chromatography, molecular modeling, molecular dynamics simulations are some of the methods he is employing in his research.

Selected publications: 

1. Burak Gulen, Anton S. Petrov, Denise C. Okafor, Drew Vander Wood, Eric B. O’Neill, Nicholas V. Hud, Loren Dean Williams, “Ribosomal Small Subunit Domains Radiate from a Central Core” (2015) (Submitted)

2. Anton S. Petrov, Burak Gulen, Ashlyn Norris, Nicholas A. Kovacs, Chad R. Bernier, Stephen C. Harvey, George E. Fox, Roger M. Wartell, Nicholas V. Hud and Loren Dean Williams, “The History of the Ribosome and the Origin of Translation” (2015) (Submitted)

3. Burak Gulen and Loren Dean Williams, “Ribosomal Protein S5 Melts the Central Pseudoknot of the 16S Ribosomal RNA” (2015) (Research Article Manuscript in Preperation)

4. Burak Gulen and Loren Dean Williams, “What We Know About the Central Pseudoknot After 30 Years” (2015) (Review Article Manuscript in Preperation)

5. Anton S. Petrov , Chad R. Bernier, Burak Gulen, Chris C. Waterbury, Eli Hershkovits, Chiaolong Hsiao, Stephen C. Harvey, Nicholas V. Hud, George E. Fox, Roger M. Wartell, Loren Dean Williams, “Secondary Structures of rRNAs from All Three Domains of Life”, (2014), PloS One, 9(2), e88222.