Roger M. Wartell

Georgia Institute of Technology, IBB

B.S. Physics, Stevens Institute of Technology

Ph.D., Physics, University of Rochester

NIH postdoctoral fellow, University of Wisconsin-Madison

Research Interests: 

I am interested in the catalytic activities of small ribozymes in solution and in the interstitial liquid phase in ice. What factors influence ribozyme catalysis and may promote their ability to create complex functional RNAs. Other areas of interest are the origin and evolution of the ribosome and the interaction of small molecules with RNA and DNA.

Selected publications: 

Mezencev R. and Wartell R.M. (2018)“Cisplatin binds to pre-miR-200b and impairs its processing to mature microRNA.” Neoplasma 65,222-227.

Wartell RM (2018) “Improving the accuracy of the nearest neighbor model of DNA melting: Comment on DNA melting and energetics of the double helix by A. Vologodskii &M.D.Frank-Kamenetskii.Physics of Life Reviews: S1571-0645(18)30015.

Lanier, K.A., Athavale, S.S., Petrov, A.S., Wartell, R.M, and Williams, L.D. (2016)"Imprint of Ancient Evolution on rRNA Folding", Biochemistry 55, 4603-4613.

Lie, L., Biliya, S. Vannberg, F. and Wartell, R.M. (2016)"Ligation of RNA Oligomers by the Schistosoma mansoni Hammerhead Ribozyme in Frozen Solution” J. Mol.Evolution 82, 81-92.

Petrov, AS, Gulen, B., Norris,AM, Bernier,CB., Kovacs,NA, Lanier,KA, Fox,GE,Harvey, SC Wartell,RM, Hud, NV and Williams, LD (2015) “The History of the Ribosome and the Origin of Translation” Proc. Natl Acad. Sci USA 112(50): 15396-15401.

Petrov, AS, Bernier, CR, Hsiao, C, Norris, AM, Kovacs, NA, Waterbury, CC, Stepanov, VG, Harvey, SC, Fox, GE, Wartell, RM, Hud, NV, and Williams, LD (2014) "Evolution of the Ribosome at Atomic Resolution", Proc. Natl. Acad. Sci. U.S.A. 111, 10251-10256.

Petrov, AS, Bernier, CR, Gulen, B, Waterbury, CC, Hershkovitz, E, Hsiao, C, Harvey, SC, Hud, NV, Fox, GE, Wartell, RM, and Williams, LD (2014) "Secondary Structures of rRNAs from All Three Domains of Life", PLoS One 9, e88222.

Hsiao, C, Lenz, TK, Peters, JK, Fang, PY, Schneider, DM, Anderson, EJ, Preeprem, T, Bowman, JC, O'Neill, EB, Lie, L, Athavale, SS, Gossett, JJ, Trippe, C, Murray, J, Petrov, AS, Wartell, RM, Harvey, SC, Hud, NV, and Williams, LD (2013) "Molecular Paleontology: A Biochemical Model of the Ancestral Ribosome", Nucleic Acids Res. 41, 3373-3385.

Hsiao, C, Chou, I-C, Okafor, CD, Bowman, JC, O'Neill, EB, Athavale, SS, Petrov, AS, Hud, NV, Wartell, RM, Harvey, SC, and Williams, LD (2013) "Iron(II) Plus RNA Can Catalyze Electron Transfer", Nature Chemistry 5, 525-528.

Athavale, SS, Petrov, AS, Hsiao, C, Watkins, D, Prickett, CD, Gossett, JJ, Lie, L, Bowman, JC, O'Neill, E, Bernier, CR, Hud, NV, Wartell, RM, Harvey, SC, and Williams, LD (2012) "RNA Folding and Catalysis Mediated by Iron (II)", PLoS ONE 7, e38024.

Athavale, SS, Gossett, JJ, Hsiao, C, Bowman, JC, O'Neill, E, Hershkovitz, E, Preeprem, T, Hud, NV, Wartell, RM, Harvey, SC, and Williams, LD (2012) "Domain III of the T. thermophilus 23S rRNA Folds Independently to a near-Native State", RNA 18, 752-758.

Updegrove, TB, and Wartell, RM (2011) "The Influence of Escherichia Coli Hfq Mutations on RNA Binding and Srna*mRNA Duplex Formation in Rpos Riboregulation", Biochim. Biophys. Acta 1809, 532-540.

Updegrove, TB, Correia, JJ, Chen, Y, Terry, C, and Wartell, RM (2011) "The Stoichiometry of the Escherichia Coli Hfq Protein Bound to RNA", RNA 17, 489-500.

Mohan, S, Hsiao, C, Bowman, JC, Wartell, R, and Williams, LD (2010) "RNA Tetraloop Folding Reveals Tension between Backbone Restraints and Molecular Interactions", J. Am. Chem. Soc. 132, 12679-12689.